Radiolabeled nano-peptides show specificity for an animal model of human PC3 prostate cancer cells
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چکیده
منابع مشابه
Radiolabeled nano‐peptides show specificity for an animal model of human PC3 prostate cancer cells
OBJECTIVES Cancer has been investigated using various pre-targeting techniques or models focusing on radiobombesin analogues; however, both are not offered together. In this study, nano-bombesin labeling by a pre-targeting system was undertaken to develop an alternative approach for prostate tumor treatment. METHODS A two-step pre-targeting system utilizing a combination of streptavidin (SA),...
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Objective(s): The stress-responsive genes of Sestrin family are recognized as new tumor suppressor genes in breast carcinoma, however, the function of Sestrin family in human prostate cancer is not clear. Ionizing radiation (IR) is known to induce Sestrin gene expression in breast cancer cells. However, the response of Sestrin to IR has not been reported in PC3 prostate cancer cells. Materials ...
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Curcumin (Cur) has been found to be very efficacious against many different types of cancercells. However, the major disadvantage associated with the use of Cur is its low systemicbioavailability. Our present work investigated the toxic effect of encapsulation of Cur in PLGA(poly lactic-coglycolic acid) nanospheres (NCur) on PC3 human cancer prostate cell. In thepresent study, we have investiga...
متن کاملAnticancer Activity of Curcumin-Loaded PLGA Nanoparticles on PC3 Prostate Cancer Cells
Curcumin (Cur) has been found to be very efficacious against many different types of cancercells. However, the major disadvantage associated with the use of Cur is its low systemicbioavailability. Our present work investigated the toxic effect of encapsulation of Cur in PLGA(poly lactic-coglycolic acid) nanospheres (NCur) on PC3 human cancer prostate cell. In thepresent study, we have investiga...
متن کاملPhysiologically Based Pharmacokinetic (PBPK) model for biodistribution of radiolabeled peptides in patients with neuroendocrine tumours
Objective(s): The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who were treatedwith Lu-177 DOTATATE. The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole body scintigraphy (WBS) of the patients.Methods: The blood...
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ژورنال
عنوان ژورنال: Clinics
سال: 2011
ISSN: 1807-5932
DOI: 10.1590/s1807-59322011000200024